Early and delayed brain SPECT with technetium-99m-ECD and iodine-123-IMP in subacute strokes.

Abstract

UNLABELLED:

The brain distribution of 99mTc-ECD versus 123I-IMP was compared in patients with subacute stroke in order to compare diagnostic accuracy.

METHODS:

A total of 25 patients with subacute stroke underwent early and delayed SPECT imaging with 99mTc-ECD and 123I-IMP. Washout of 99mTc-ECD was calculated and a differential percentage of activity (DPA) of ischemic versus normal zones was assessed. Images were analyzed twice by five independent observers.

RESULTS:

Technetium-99m-ECD clearance was 12.5% from the whole brain during early imaging. Ischemic parietal zones had higher clearance than normal parietal zones. Technetium-99m-ECD images showed larger differences between abnormal and normal brain activity than 123I-IMP images. Detection accuracy was slightly, but not significantly, higher for 99mTc-ECD and 123I-IMP (sensitivity: 73.8% as 66.6%; specificity: 81.7% as 81.6%). Reproducibility among observers was similar for 99mTc-ECD and early 123I-IMP.

CONCLUSION:

Technetium-99m-ECD demonstrates high diagnostic accuracy during subacute stroke, similar to 123I-IMP, but with more intense, better delineation of the perfusion defects.

• Authors: J L Moretti, F Tamgac, P Weinmann, N Caillat-Vigneron, C A Belin, P Cesaro, B L Holman, G Defer
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 35 Issue 9 Pg. 1444-9 (Sep 1994) ISSN: 0161-5505 [Print] United States
• PMID: 8071689 (Publication Type: Journal Article)

Chemical References

• Amphetamines
• Iodine Radioisotopes
• Organotechnetium Compounds
• Iofetamine
• technetium Tc 99m bicisate
• Cysteine

Topics

• Adult
• Aged
• Aged, 80 and over
• Amphetamines
• Brain (diagnostic imaging)
• Cerebrovascular Disorders (diagnostic imaging)
• Cysteine (analogs & derivatives)
• Female
• Humans
• Iodine Radioisotopes
• Iofetamine
• Male
• Middle Aged
• Models, Structural
• Organotechnetium Compounds
• Sensitivity and Specificity
• Time Factors
• Tomography, Emission-Computed, Single-Photon