Abstract |
The in vitro activity of cefodizime and two comparative cephalosporins, cefuroxime and ceftriaxone were studied against respiratory pathogens. MIC90s of cefodizime were 0.06-0.512 microgram/ml for Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae. MIC50s of cefodizime for Klebsiella pneumoniae and Staphylococcus aureus isolates were 2 micrograms/ml and 8 micrograms/ml respectively. Cefuroxime and ceftriaxone at a concentration of 2 micrograms/ml and 1 microgram/ml inhibited 50% of Klebsiella pneumoniae and 50% of Staphylococcus aureus strains studied respectively. Cefodizime inhibited many of the important respiratory pathogens and can be suggested as an active antimicrobial agent for respiratory tract infections.
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Authors | O Paniara, E Platsouka, H Dimopoulou, S Constantoulaki |
Journal | Journal of chemotherapy (Florence, Italy)
(J Chemother)
Vol. 6
Issue 1
Pg. 35-8
(Feb 1994)
ISSN: 1120-009X [Print] England |
PMID | 8071676
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ceftriaxone
- Cefotaxime
- Cefuroxime
- cefodizime
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Topics |
- Cefotaxime
(analogs & derivatives, pharmacology)
- Ceftriaxone
(pharmacology)
- Cefuroxime
(pharmacology)
- Haemophilus Infections
(microbiology)
- Haemophilus influenzae
(drug effects)
- Humans
- Klebsiella Infections
(microbiology)
- Klebsiella pneumoniae
(drug effects)
- Microbial Sensitivity Tests
- Moraxella catarrhalis
(drug effects)
- Neisseriaceae Infections
(microbiology)
- Pneumococcal Infections
(microbiology)
- Respiratory Tract Infections
(microbiology)
- Staphylococcal Infections
(microbiology)
- Staphylococcus aureus
(drug effects)
- Streptococcus pneumoniae
(drug effects)
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