Effects of natural antioxidant ginkgo biloba extract (EGB 761) on myocardial ischemia-reperfusion injury.

Abstract	Recently, it was reported that Ginkgo biloba extract (EGb 761), which is known to have antioxidant properties, also has antiarrhythmic effects on cardiac reperfusion-induced arrhythmias. In the present study, effects of EGb 761 on cardiac ischemia-reperfusion injury were investigated from the point of view of recovery of mechanical function as well as the endogenous antioxidant status of ascorbate. Isolated rat hearts were perfused using the Langendorff technique, and 40 min of global ischemia were followed by 20 min of reperfusion. EGb 761 improved cardiac mechanical recovery and suppressed the leakage of lactate dehydrogenase (LDH) during reperfusion. Furthermore, EGb 761 diminished the decrease of myocardial ascorbate content after 40 min of ischemia and 20 min of reperfusion. Interestingly, EGb 761 also suppressed the increase of dehydroascorbate. These results indicate that EGb 761 protects against cardiac ischemia-reperfusion injury and suggest that the protective effects of EGb 761 depend on its antioxidant properties.
Authors	N Haramaki, S Aggarwal, T Kawabata, M T Droy-Lefaix, L Packer
Journal	Free radical biology & medicine (Free Radic Biol Med) Vol. 16 Issue 6 Pg. 789-94 (Jun 1994) ISSN: 0891-5849 [Print] United States
PMID	8070682 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Antioxidants Plant Extracts Ginkgo biloba extract L-Lactate Dehydrogenase Ascorbic Acid Dehydroascorbic Acid
Topics	Analysis of Variance Animals Antioxidants (pharmacology) Ascorbic Acid (metabolism) Dehydroascorbic Acid (metabolism) Electron Spin Resonance Spectroscopy Ginkgo biloba Heart (drug effects, physiopathology) In Vitro Techniques L-Lactate Dehydrogenase (analysis) Male Myocardial Ischemia (physiopathology) Myocardium (enzymology) Plant Extracts (pharmacology) Rats Rats, Sprague-Dawley Reperfusion Reperfusion Injury (physiopathology, prevention & control) Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!