A double-blind, vehicle-controlled study of the safety and efficacy of Fungoid Tincture in patients with distal subungual onychomycosis of the toes.

Abstract	Onychomycosis is one of the most common causes of nail disease and one of the hardest to treat among fungal infections. A double-blind, vehicle-controlled study has been conducted to evaluate the safety and efficacy of Fungoid Tincture (Pedinol Pharmacal, Inc), for the treatment of fungal infection of the toenails. Ten patients with distal subungual onychomycosis were treated for twelve months with topical Fungoid Tincture. Another ten patients with the same ailment were treated with the vehicle alone. Once a month, clinical and global evaluation of the target nail was done, in addition to trimming and debridement of the nails. After twelve months of treatment, 90 percent of patients applying Fungoid Tincture showed negative results on culture. There were minimal adverse effects.
Authors	J B Montana, R K Scher
Journal	Cutis (Cutis) Vol. 53 Issue 6 Pg. 313-6 (Jun 1994) ISSN: 0011-4162 [Print] United States
PMID	8070287 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References	Antifungal Agents Benzalkonium Compounds Drug Combinations Fungoid Tincture Pharmaceutical Vehicles Propionates Xylenes Cetylpyridinium Triacetin
Topics	Administration, Cutaneous Adolescent Adult Aged Antifungal Agents (administration & dosage, adverse effects, therapeutic use) Benzalkonium Compounds (administration & dosage, adverse effects, therapeutic use) Cetylpyridinium (administration & dosage, adverse effects, analogs & derivatives, therapeutic use) Double-Blind Method Drug Combinations Female Foot Dermatoses (drug therapy, microbiology) Humans Male Middle Aged Onychomycosis (drug therapy) Pharmaceutical Vehicles Propionates (administration & dosage, adverse effects, therapeutic use) Safety Toes Triacetin (administration & dosage, adverse effects, therapeutic use) Xylenes (administration & dosage, adverse effects, therapeutic use)

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