Abstract |
15 children with ALL and chemotherapy related neutropenia were treated with GM-CSF ( Leucomax-Sandoz/Schering-Plough) in a dose of 5 micrograms/kg b.w./day during 7-10 days. Altogether 21 cycles were performed. Increase in the number of neutrophils in the majority of cases was observed already after 3 days of GM-CSF administration. The median time of neutropenia recovery was shorter in children treated with GM-CSF than in the control group. The frequency of severe infections was also significantly lower. No serous side effects were observed.
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Authors | R Rokicka-Milewska, D Derulska, K Pawelec |
Journal | Acta haematologica Polonica
(Acta Haematol Pol)
Vol. 25
Issue 2
Pg. 111-8
( 1994)
ISSN: 0001-5814 [Print] Poland |
Vernacular Title | Zastosowanie rHu GM-CSF (Leucomax) w leczeniu neutropenii w przebiegu intensywnej chemioterapii ostrej biaĆaczki limfoblastycznej (obl). |
PMID | 8067182
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Recombinant Proteins
- Granulocyte-Macrophage Colony-Stimulating Factor
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Topics |
- Adolescent
- Child
- Child, Preschool
- Female
- Granulocyte-Macrophage Colony-Stimulating Factor
(therapeutic use)
- Humans
- Male
- Neutropenia
(drug therapy, etiology)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(complications, drug therapy)
- Recombinant Proteins
(therapeutic use)
- Treatment Outcome
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