[The modulation of cellular immunity in vivo and in vitro under the action of purified staphylococcal anatoxin].

Abstract

Purified staphylococcal toxoid modulates (mainly suppresses) cell-mediated immune response to heterogeneous antigens of animal origin (to sheep red blood cells as shown by the delayed hypersensitivity reaction) or bacterial origin (to BCG as shown by the splenocyte migration test). The direction and manifestation of modulation depend on the strain of mice, dose of the toxoid, dose and nature of the test antigen and the immunization schedule (intervals between the injections of the antigen).

• Authors: I B Semenova, A K Akatov
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) 1993 Jan-Feb Issue 1 Pg. 65-8 ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Moduliatsiia kletochnogo immuniteta in vivo i in vitro pod deĭstviem anatoksina stafilokokkovogo ochishchennogo.
• PMID: 8067075 (Publication Type: English Abstract, Journal Article)

Chemical References

• BCG Vaccine
• Staphylococcal Toxoid

Topics

• Animals
• BCG Vaccine (immunology)
• Cell Migration Inhibition
• Dose-Response Relationship, Immunologic
• Hypersensitivity, Delayed (immunology)
• Immunity, Cellular (drug effects)
• Immunization
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Spleen (drug effects, immunology)
• Staphylococcal Toxoid (isolation & purification, pharmacology)
• Time Factors