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Humoral immune response to the Trypanosoma cruzi complement regulatory protein as an indicator of parasitologic clearance in human Chagas' disease.

Abstract
Immunoprecipitation of the purified 160-kDa complement regulatory protein of Trypanosoma cruzi by Chagas' disease patient sera was examined as a possible correlate of the complement-mediated lysis test and as an indicator of parasite clearance. The results presented demonstrate that assessment of the humoral response to this antigen is a useful indicator of parasite clearance and may be particularly helpful in the assessment of some patients for whom other serological tests produce ambiguous results.
AuthorsK A Norris, L M Galvão, J E Schrimpf, J R Cançado, A U Krettli
JournalInfection and immunity (Infect Immun) Vol. 62 Issue 9 Pg. 4072-4 (Sep 1994) ISSN: 0019-9567 [Print] United States
PMID8063427 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies, Protozoan
  • Protozoan Proteins
  • Complement System Proteins
Topics
  • Animals
  • Antibodies, Protozoan (blood)
  • Chagas Disease (immunology, parasitology)
  • Complement System Proteins (immunology)
  • Humans
  • Protozoan Proteins (immunology)
  • Trypanosoma cruzi (immunology)

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