Enhancement of gastric mucosal blood flow with sulglycotide.

Abstract	Twelve patients with dyspepsia whose gastric abnormalities ranged from diffuse reddening of the mucosa to multiple erosions were treated for 4 weeks with oral sulglycotide, a sulphated glycopeptide with known gastroprotective and ulcer-healing properties. Before and after treatment, gastric mucosal blood flow was assessed by means of laser Doppler flowmetry. A significant (P < 0.01) increase in mucosal perfusion was observed after sulglycotide treatment, suggesting that enhancement of mucosal blood flow may contribute to the therapeutic properties of the drug.
Authors	M Guslandi, M Sorghi, A Tittobello
Journal	Clinical therapeutics (Clin Ther) 1994 Mar-Apr Vol. 16 Issue 2 Pg. 141-4; discussion 140 ISSN: 0149-2918 [Print] United States
PMID	8062309 (Publication Type: Journal Article)
Chemical References	Anti-Ulcer Agents Sialoglycoproteins sulglicotide
Topics	Administration, Oral Adult Anti-Ulcer Agents (pharmacology, therapeutic use) Dyspepsia (drug therapy) Female Gastric Mucosa (blood supply, drug effects, physiopathology) Gastroscopy Humans Laser-Doppler Flowmetry Male Middle Aged Sialoglycoproteins (pharmacology, therapeutic use)

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