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Isolation of an adhesin from Staphylococcus aureus that binds Lewis a blood group antigen and its relevance to sudden infant death syndrome.

Abstract
A 67 kDa protein was isolated from cell membrane preparations of Staphylococcus aureus (NCTC 10655) by affinity adsorption with synthetic Lewis a antigen conjugated to Synsorb beads. Pre-treatment of buccal epithelial cells expressing Lewis a with the purified protein reduced binding of the staphylococcal strain to a greater extent than the material not bound to the Synsorb beads. The significance of this work is discussed with reference to expression of Lewis a antigen in infants and the proposed role of toxigenic strains of staphylococci in some cases of sudden infant death syndrome.
AuthorsA T Saadi, D M Weir, I R Poxton, J Stewart, S D Essery, C C Blackwell, M W Raza, A Busuttil
JournalFEMS immunology and medical microbiology (FEMS Immunol Med Microbiol) Vol. 8 Issue 4 Pg. 315-20 (May 1994) ISSN: 0928-8244 [Print] England
PMID8061655 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adhesins, Bacterial
  • Lewis Blood Group Antigens
  • adhesin, Staphylococcus aureus
Topics
  • Adhesins, Bacterial
  • Bacterial Adhesion (immunology, physiology)
  • Binding, Competitive
  • Cell Wall (chemistry)
  • Cheek
  • Chromatography, Affinity
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Infant
  • Lewis Blood Group Antigens (metabolism)
  • Mouth Mucosa (cytology)
  • Staphylococcus aureus (immunology)
  • Sudden Infant Death (etiology)

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