Abstract |
A 67 kDa protein was isolated from cell membrane preparations of Staphylococcus aureus (NCTC 10655) by affinity adsorption with synthetic Lewis a antigen conjugated to Synsorb beads. Pre-treatment of buccal epithelial cells expressing Lewis a with the purified protein reduced binding of the staphylococcal strain to a greater extent than the material not bound to the Synsorb beads. The significance of this work is discussed with reference to expression of Lewis a antigen in infants and the proposed role of toxigenic strains of staphylococci in some cases of sudden infant death syndrome.
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Authors | A T Saadi, D M Weir, I R Poxton, J Stewart, S D Essery, C C Blackwell, M W Raza, A Busuttil |
Journal | FEMS immunology and medical microbiology
(FEMS Immunol Med Microbiol)
Vol. 8
Issue 4
Pg. 315-20
(May 1994)
ISSN: 0928-8244 [Print] England |
PMID | 8061655
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adhesins, Bacterial
- Lewis Blood Group Antigens
- adhesin, Staphylococcus aureus
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Topics |
- Adhesins, Bacterial
- Bacterial Adhesion
(immunology, physiology)
- Binding, Competitive
- Cell Wall
(chemistry)
- Cheek
- Chromatography, Affinity
- Electrophoresis, Polyacrylamide Gel
- Humans
- Infant
- Lewis Blood Group Antigens
(metabolism)
- Mouth Mucosa
(cytology)
- Staphylococcus aureus
(immunology)
- Sudden Infant Death
(etiology)
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