Immunotoxic organotins as possible model compounds in studying apoptosis and thymocyte differentiation.

Abstract

In the mid-seventies it appeared that some organotin compounds selectively caused thymus atrophy. From that time onward efforts were made to reveal molecular and cellular mechanisms involved. In this review recent studies into organotin-sensitive stages and processes of thymocyte maturation are discussed. Together these studies resulted in the recognition of organotin compounds as possible model compounds in studying immature thymocyte differentiation and protein synthesis-independent apoptotic cell death of thymocytes.

• Authors: R H Pieters, M Bol, A H Penninks
• Journal: Toxicology (Toxicology) Vol. 91 Issue 2 Pg. 189-202 (Jul 01 1994) ISSN: 0300-483X [Print] Ireland
• PMID: 8059442 (Publication Type: Journal Article, Review)

Chemical References

• Organotin Compounds

Topics

• Animals
• Apoptosis (drug effects, immunology)
• Atrophy
• Cell Differentiation (drug effects)
• Cell Division (drug effects)
• Models, Biological
• Organotin Compounds (immunology, toxicity)
• Thymus Gland (drug effects, immunology, pathology)