[A comparative study of the antiarrhythmic action of bonnecor and the mesidide derivatives of alpha-azacycloalkane carboxylic acids].

Abstract

The antiarrhythmic properties of the dibenzazepine derivative bonnecor and derivatives of mesidides of alpha-azacycloalkanocarboxylic acids were studied in various experimental arrhythmia models. The comparative study revealed different antiarrhythmic effects in different arrhythmia models. Bonnecor was found to have a higher antiarrhythmic activity in most arrhythmic models. Tertiary salts were demonstrated to be more potent than quaternary ones.

• Authors: N Sh Paliani-Katsitadze, S Iu Berdiaev, A I Turilova, N V Kaverina, A M Likhosherstov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1994 May-Jun Vol. 57 Issue 3 Pg. 15-7 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'noe izuchenie antiaritmicheskogo deĭstviia bonnekora i nekotorykh proizvodnykh mezididov al'fa-azatsikloalkankarbonovyykh kislot.
• PMID: 8049618 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Aniline Compounds
• Anti-Arrhythmia Agents
• Dibenzazepines
• Lidocaine
• tiracizine
• Procainamide
• Aconitine

Topics

• Aconitine
• Aniline Compounds (pharmacology, therapeutic use, toxicity)
• Animals
• Anti-Arrhythmia Agents (pharmacology, therapeutic use, toxicity)
• Arrhythmias, Cardiac (drug therapy, etiology)
• Cats
• Dibenzazepines (pharmacology, therapeutic use, toxicity)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Heart Rate (drug effects)
• In Vitro Techniques
• Lethal Dose 50
• Lidocaine (therapeutic use)
• Procainamide (therapeutic use)
• Rats
• Structure-Activity Relationship