Abstract |
We report a 59-year-old woman who had subcorneal pustular dermatosis and IgA-kappa myeloma. Immunofluorescence tests showed intercellular IgA-kappa deposits in the upper portion of the lesional epidermis and circulating IgA-kappa anti-intercellular autoantibodies in a titer of 1:40. A combination chemotherapy for myeloma induced dramatic improvement of the skin lesions in accordance with a marked decrease in serum IgA levels as well as the disappearance of circulating anti-intercellular IgA autoantibodies, suggesting a pathogenetic link between skin lesions and IgA-kappa paraprotein produced by myeloma cells.
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Authors | M Takata, M Inaoki, M Shodo, T Hirone, H Kaya |
Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 189 Suppl 1
Pg. 111-4
( 1994)
ISSN: 1018-8665 [Print] Switzerland |
PMID | 8049547
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Autoantibodies
- Immunoglobulin A
- Immunoglobulin kappa-Chains
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Topics |
- Autoantibodies
(analysis)
- Female
- Fluorescent Antibody Technique
- Humans
- Immunoglobulin A
(analysis)
- Immunoglobulin kappa-Chains
(analysis)
- Middle Aged
- Multiple Myeloma
(complications, immunology)
- Skin
(immunology)
- Skin Diseases, Vesiculobullous
(complications, immunology)
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