HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Subcorneal pustular dermatosis associated with IgA myeloma and intraepidermal IgA deposits.

Abstract
We report a 59-year-old woman who had subcorneal pustular dermatosis and IgA-kappa myeloma. Immunofluorescence tests showed intercellular IgA-kappa deposits in the upper portion of the lesional epidermis and circulating IgA-kappa anti-intercellular autoantibodies in a titer of 1:40. A combination chemotherapy for myeloma induced dramatic improvement of the skin lesions in accordance with a marked decrease in serum IgA levels as well as the disappearance of circulating anti-intercellular IgA autoantibodies, suggesting a pathogenetic link between skin lesions and IgA-kappa paraprotein produced by myeloma cells.
AuthorsM Takata, M Inaoki, M Shodo, T Hirone, H Kaya
JournalDermatology (Basel, Switzerland) (Dermatology) Vol. 189 Suppl 1 Pg. 111-4 ( 1994) ISSN: 1018-8665 [Print] Switzerland
PMID8049547 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Autoantibodies
  • Immunoglobulin A
  • Immunoglobulin kappa-Chains
Topics
  • Autoantibodies (analysis)
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Immunoglobulin A (analysis)
  • Immunoglobulin kappa-Chains (analysis)
  • Middle Aged
  • Multiple Myeloma (complications, immunology)
  • Skin (immunology)
  • Skin Diseases, Vesiculobullous (complications, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: