| Abstract | We report a 59-year-old woman who had subcorneal pustular dermatosis and IgA-kappa myeloma. Immunofluorescence tests showed intercellular IgA-kappa deposits in the upper portion of the lesional epidermis and circulating IgA-kappa anti-intercellular autoantibodies in a titer of 1:40. A combination chemotherapy for myeloma induced dramatic improvement of the skin lesions in accordance with a marked decrease in serum IgA levels as well as the disappearance of circulating anti-intercellular IgA autoantibodies, suggesting a pathogenetic link between skin lesions and IgA-kappa paraprotein produced by myeloma cells. |
| Authors | M Takata, M Inaoki, M Shodo, T Hirone, H Kaya
(Affiliation: Department of Dermatology, Kanazawa University School of Medicine, Japan.)
|
| Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 189 Suppl 1
Pg. 111-4
( 1994)
ISSN: 1018-8665 SWITZERLAND |
| PMID | 8049547
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Autoantibodies
- Immunoglobulin A
- Immunoglobulin kappa-Chains
|
| Topics |
- Autoantibodies
(analysis)
- Female
- Fluorescent Antibody Technique
- Humans
- Immunoglobulin A
(analysis)
- Immunoglobulin kappa-Chains
(analysis)
- Middle Aged
- Multiple Myeloma
(complications, immunology)
- Skin
(immunology)
- Skin Diseases, Vesiculobullous
(complications, immunology)
|
