[Uterine-placental-fetal blood flow and fetal cardiac activity during the ginipral treatment of premature labor].

Abstract

Effects of intravenous and oral hinipral on the uteroplacentofetal blood flow and fetal heart work were studied in tocolytic therapy of preterm labor in 27 pregnant women at terms 25-35 weeks. Intravenous infusions of hinipral resulted in a significant reduction of the systolic-diastolic ratio in the umbilical artery, with the blood flow in the uterine arteries persisting stable, and in a significant reduction of the fetal heart rate and increase of fetal heart rhythm variability, as evidenced by cardiotocogram. In oral tocolysis the reduction of the umbilical artery was related to the pregnancy term; fetal heart rate and heart rhythm variability were within the normal range over the course of the investigation. The results evidence no negative effects of the drug on the uteroplacentofetal blood flow and fetal cardiovascular system both in oral and parenteral forms of tocolysis.

• Authors: A N Strizhakov, M V Medvedev, L G Kovaleva
• Journal: Akusherstvo i ginekologiia (Akush Ginekol (Mosk)) Issue 2 Pg. 24-30 ( 1993) ISSN: 0300-9092 [Print] Russia (Federation)
• Vernacular Title: Sostoianie matochno-platsentarno-plodovogo krovotoka i serdechnoĭ deiatel'nosti ploda pri lechenii ginipralom prezhdevremennykh rodov.
• PMID: 8048664 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Tocolytic Agents
• Hexoprenaline

Topics

• Abortion, Threatened (drug therapy, physiopathology)
• Adult
• Drug Evaluation
• Female
• Fetal Heart (drug effects, physiology)
• Fetus (blood supply, drug effects)
• Hexoprenaline (pharmacology, therapeutic use)
• Humans
• Obstetric Labor, Premature (drug therapy, physiopathology)
• Placenta (blood supply, drug effects)
• Pregnancy
• Regional Blood Flow (drug effects)
• Tocolytic Agents (pharmacology, therapeutic use)
• Uterine Contraction (drug effects)
• Uterus (blood supply, drug effects)