Abstract |
The effects of traditional Chinese medicine ( Sairei-to) on monoclonal antibody (mAb) inducing proteinuria were examined. Four hundred, 200 and 100 mg/kg body weight (BW) of Sairei-to and phosphate-buffered saline (PBS) as a control were injected intraperitoneally into four groups of female Wistar rats every day from 5 days before intravenous injection of mAb to the end of the experimental period. The amount of urinary protein excretion was significantly suppressed in roughly a dose-dependent manner. For example, 116.6 +/- 89.7 mg/day of proteinuria was observed in control groups compared to 4.2 +/- 15.2 mg/day in the 400 mg/kg BW of Sairei-to treated group 2 days after mAb injection (P < 0.01). Statistically significant (P < 0.01) differences were again observed in a repeat experiment (122.1 +/- 53.7 vs 10.2 +/- 10.1 mg/day on the 2nd day) without affecting the glomerular filtration rate. No significant difference was recognized between the total amount of mAb bound to glomeruli 1 h after mAb injection in Sairei-to-treated and non-treated rats, indicating that Sairei-to pretreatment has no effects on the number or quality of antigenic molecules. The effect of Sairei-to on a non-immunological model of proteinuria was also examined. No significant reduction of proteinuria by similar Sairei-to treatment was observed in aminonucleoside of puromycin nephropathy. The authors conclude that mAb-induced proteinuria in rats is significantly suppressed by the traditional Chinese medicine, Sairei-to.
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Authors | H Kawachi, N Takashima, M Orikasa, T Oite, F Shimizu |
Journal | Pathology international
(Pathol Int)
Vol. 44
Issue 5
Pg. 339-44
(May 1994)
ISSN: 1320-5463 [Print] Australia |
PMID | 8044302
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Drugs, Chinese Herbal
- sairei-to
- Puromycin Aminonucleoside
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Topics |
- Animals
- Antibodies, Monoclonal
- Drugs, Chinese Herbal
(therapeutic use)
- Female
- Fluorescent Antibody Technique
- Nephritis
(chemically induced, drug therapy)
- Proteinuria
(drug therapy, immunology)
- Puromycin Aminonucleoside
- Rats
- Rats, Wistar
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