Abstract |
The aim of this study was to assess the effectiveness and safety of intracavernous injections of a four- drug vasoactive mixture in diabetic patients with organic impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic impotence were treated with intracavernous injections of a combination of 12.1 mg/ml papaverine hydrochloride, 1.01 mg/ml phentolamine mesylate, 10.1 micrograms/ml prostaglandin E1 and 0.15 mg/ml atropine sulphate ('full-dose' mixture). A mixture of the same drugs but at one-third concentrations ('reduced-dose' mixture) was also used. The mean (+/- SEM) volumes of the full-dose and reduced-dose mixtures used were 0.21 +/- 0.03 ml and 0.31 +/- 0.02 ml, respectively. All the patients were able to sustain a rigid erection at the end of the titration phase of the study. At a mean follow-up of 18 months, 48 patients (80%) were successfully using the mixture, 6 patients (10%) were using the mixture at a dose lower than the initial dose and 6 patients (10%) had dropped out from the injection therapy. No major complications were seen. The association of multiple vasoactive drugs which use different mechanisms of action, thus exerting a pharmacological synergism, is an effective and safe procedure in intracavernous pharmacotherapy for diabetic patients with organic impotence.
|
Authors | F Montorsi, G Guazzoni, F Bergamaschi, M Zucconi, P Rigatti, G Pizzini, A Miani, G Pozza |
Journal | Acta diabetologica
(Acta Diabetol)
Vol. 31
Issue 1
Pg. 1-5
(Apr 1994)
ISSN: 0940-5429 [Print] Germany |
PMID | 8043890
(Publication Type: Journal Article)
|
Chemical References |
- Drug Combinations
- Atropine
- Papaverine
- Alprostadil
- Phentolamine
|
Topics |
- Adult
- Aged
- Alprostadil
(administration & dosage, therapeutic use)
- Atropine
(administration & dosage, therapeutic use)
- Diabetes Complications
- Drug Combinations
- Erectile Dysfunction
(drug therapy, etiology, physiopathology)
- Follow-Up Studies
- Humans
- Injections
- Male
- Middle Aged
- Papaverine
(administration & dosage, therapeutic use)
- Penile Erection
(drug effects)
- Phentolamine
(administration & dosage, therapeutic use)
- Self Administration
- Treatment Outcome
|