alpha-Tocopherol protects against radical-induced injury in cultured neurons.

Abstract

The effect of alpha-tocopherol on neurons in protecting against radical-induced injuries caused by cumene hydroperoxide was assessed using a culture system. Structural and biochemical deteriorations in both clonal neuroblastoma cells and primary cultured neurons were induced by cumene hydroperoxide. These deteriorative changes were prevented prevented by pretreatment of alpha-tocopherol. Since simultaneous supplementation of alpha-tocopherol and cumene hydroperoxide had limited protective effects, prophylactic administration of alpha-tocopherol for risk patients with brain diseases concerned with damages induced by free radical is recommended to hamper the progression of neuronal impairment after attacks.

• Authors: S Amano, M Ohashi, M Kirihara, X H Yang, F Hazama
• Journal: Neuroscience letters (Neurosci Lett) Vol. 170 Issue 1 Pg. 55-8 (Mar 28 1994) ISSN: 0304-3940 [Print] Ireland
• PMID: 8041514 (Publication Type: Journal Article)

Chemical References

• Benzene Derivatives
• Free Radicals
• Thiobarbituric Acid Reactive Substances
• Vitamin E
• L-Lactate Dehydrogenase
• cumene hydroperoxide

Topics

• Animals
• Benzene Derivatives (toxicity)
• Cells, Cultured
• Clone Cells
• Free Radicals (adverse effects)
• L-Lactate Dehydrogenase (metabolism)
• Lipid Peroxidation (drug effects)
• Mice
• Neurons (drug effects, enzymology, ultrastructure)
• Rats
• Thiobarbituric Acid Reactive Substances (metabolism)
• Tumor Cells, Cultured
• Vitamin E (pharmacology)