The recognition of cancer-associated fucosylated antigens in colorectal cancer by a novel monoclonal antibody, YB-2.

Abstract

A monoclonal antibody, YB-2, which has a novel epitope for fucosylated antigens and shows cross-reactivity with Y/Leb/H type 2 antigens, was used in an immunohistochemical study of human neoplastic and normal colorectal tissues. Of 64 colorectal cancers, 59 (92.2%) were stained by the YB-2 antibody; however, only 3 (12.0%) of 25 samples of normal colon mucosa and 13 (50.0%) of 26 adenomas expressed the antigens recognized by YB-2. Clinicopathologically, the YB-2-negative colon cancers were exclusively in Dukes stage A. These results indicate that the monoclonal antibody, YB-2, could detect cancer-associated antigens, and the degree of YB-2-reacted antigen expression might be correlated with the progression of colorectal carcinogenesis.

• Authors: H Naitoh, S Yazawa, T Asao, T Nakajima, J Nakamura, S Takenoshita, Y Nagamachi
• Journal: Surgery today (Surg Today) Vol. 24 Issue 4 Pg. 382-4 ( 1994) ISSN: 0941-1291 [Print] Japan
• PMID: 8038519 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antigens, Neoplasm

Topics

• Adenoma (immunology, pathology)
• Antibodies, Monoclonal (immunology)
• Antigens, Neoplasm (analysis)
• Carcinoma (immunology, pathology)
• Colorectal Neoplasms (immunology, pathology)
• Humans
• Neoplasm Staging