Abstract | PURPOSE: Acquired inhibitors to coagulation factors are rare in pediatric patients. Exposure to topical bovine thrombin is a risk factor for the development of inhibitors in adult cardiac surgery patients. We report two pediatric patients who developed inhibitors to bovine and human factor V after exposure to fibrin glue containing bovine thrombin. PATIENTS AND METHODS: The two patients, ages 3 1/2 years and 10 months, were studied after cardiac surgery. One patient had clinical bleeding. Coagulation factor assays and inhibitor studies were performed. RESULTS: The presence of a circulating inhibitor to bovine factor V was observed in both patients and to human factor V in one patient. The inhibition of bovine factor V interfered with standard assays for factor VIII activity using a commercial substrate fortified with bovine factor V resulting in spurious factor VIII deficiency. In one patient, an inhibitor of bovine thrombin was also identified. The inhibition of human factor V activity in one patient may have contributed to clinical bleeding. CONCLUSIONS:
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Authors | S J Israels, E D Israels |
Journal | The American journal of pediatric hematology/oncology
(Am J Pediatr Hematol Oncol)
Vol. 16
Issue 3
Pg. 249-54
(Aug 1994)
ISSN: 0192-8562 [Print] United States |
PMID | 8037345
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies
- Factor V
- Thrombin
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Topics |
- Administration, Topical
- Animals
- Antibodies
(analysis)
- Cattle
- Child, Preschool
- Factor V
(antagonists & inhibitors, immunology)
- Female
- Humans
- Infant
- Male
- Thrombin
(administration & dosage, antagonists & inhibitors, immunology)
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