Abstract |
The effect on the oropharyngeal and intestinal microflora and the efficacy and tolerance of loracarbef (200 mg b.i.d. for 7 days) versus amoxicillin (500 mg t.i.d. for 7 days) were compared in 80 patients with bronchitis. The oropharyngeal samples of 18% of patients in the amoxicillin group and 5% of patients in the loracarbef group revealed a new Gram-negative species around days 8-10. The presence of other aerobic bacteria than found at baseline in the faeces occurred in 38% of patients treated with amoxicillin compared with 31% in the loracarbef group on days 8-10. After treatment, no loracarbef- or amoxicillin-resistant aerobic Gram-negative bacteria were found in faecal samples in the loracarbef group, while amoxicillin- or loracarbef-resistant (E. coli) strains appeared in 35% of patients receiving amoxicillin (p < 0.001). Treatment success occurred by days 8-10 in all 40 patients receiving loracarbef, compared with 90% in the amoxicillin group, on days 21-28, in 93% and 90% respectively. The results of this study indicate that the use of loracarbef leads to minor changes in the normal oropharyngeal and intestinal microflora compared with amoxicillin, while almost no resistant Gram-negative bacteria emerge after treatment with loracarbef.
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Authors | M Floor, F van Akkeren, M Rozenberg-Arska, M Visser, A Kolsters, H Beumer, J Verhoef |
Journal | Scandinavian journal of infectious diseases
(Scand J Infect Dis)
Vol. 26
Issue 2
Pg. 191-7
( 1994)
ISSN: 0036-5548 [Print] England |
PMID | 8036475
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cephalosporins
- loracarbef
- Amoxicillin
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Topics |
- Acute Disease
- Adolescent
- Adult
- Amoxicillin
(adverse effects, pharmacology, therapeutic use)
- Bacteria, Anaerobic
(isolation & purification)
- Bronchitis
(drug therapy, microbiology)
- Cephalosporins
(adverse effects, pharmacology, therapeutic use)
- Enterococcus faecalis
(isolation & purification)
- Female
- Gram-Negative Aerobic Bacteria
(isolation & purification)
- Humans
- Intestines
(drug effects, microbiology)
- Male
- Microbial Sensitivity Tests
- Oropharynx
(drug effects, microbiology)
- Yeasts
(isolation & purification)
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