Use of antibiotic-PMMA beads in the ischemic foot.

Abstract

Thirty-six patients with 44 ischemic foot infections were managed with antibiotic-polymethylmethacrylate (PMMA) beads. Most of these patients received gentamicin-impregnated PMMA beads but tobramycin and vancomycin-impregnated PMMA beads were used on three patients. Angiopathy occurred in 35 patients secondary to diabetes and secondary to renal disease in 2; 1 patient had both diabetes and renal disease. The most common bacteria was Staphylococcus aureus (82%), although other organisms and multiple bacteria were present. In spite of the variability of the bacteria, PMMA beads were helpful in managing foot infections in this difficult patient population.

• Authors: J H Calhoun, K Klemm, D M Anger, J T Mader
• Journal: Orthopedics (Orthopedics) Vol. 17 Issue 5 Pg. 453-7; discussion 458 (May 1994) ISSN: 0147-7447 [Print] United States
• PMID: 8036189 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Drug Implants
• Gentamicins
• Methylmethacrylates
• gentamicin-polymethylmethacrylate bead

Topics

• Anti-Bacterial Agents (administration & dosage)
• Drug Implants
• Female
• Foot (blood supply)
• Foot Diseases (drug therapy, microbiology)
• Gentamicins (therapeutic use)
• Humans
• Infections (drug therapy, etiology)
• Ischemia (complications)
• Male
• Methylmethacrylates (therapeutic use)
• Middle Aged