Enantioselective inhibition of apomorphine-induced emesis in the ferret by the neurokinin1 receptor antagonist CP-99,994.

Abstract

These studies have examined the effects of the selective neurokinin1 (NK1) receptor antagonist CP-99,994 on the retching and vomiting response to apomorphine. CP-99,994 (1-3 mg/kg i.p.) attenuated retching and vomiting induced by apomorphine (0.25 mg/kg s.c.) with complete inhibition of retching and vomiting at the 3 mg/kg dose. In contrast CP-100,263 (3 mg/kg i.p.), the enantiomer of CP-99,994 with 1000-fold lower affinity for the NK1 receptor, was without effect.

• Authors: F D Tattersall, W Rycroft, R G Hill, R J Hargreaves
• Journal: Neuropharmacology (Neuropharmacology) Vol. 33 Issue 2 Pg. 259-60 (Feb 1994) ISSN: 0028-3908 [Print] England
• PMID: 8035913 (Publication Type: Journal Article)

Chemical References

• Neurokinin-1 Receptor Antagonists
• Piperidines
• 3-(2-methoxybenzylamino)-2-phenylpiperidine
• Apomorphine

Topics

• Animals
• Apomorphine (antagonists & inhibitors)
• Dose-Response Relationship, Drug
• Ferrets
• Male
• Neurokinin-1 Receptor Antagonists
• Piperidines (pharmacology)
• Stereoisomerism
• Vomiting (chemically induced, prevention & control)