Abstract | OBJECTIVES: BACKGROUND: METHODS: Seventeen consecutive young patients (mean age 15 years, range 10 to 18; 7 male, 10 female) with recurrent syncope and a positive head-upright tilt table test, and in whom standard therapies ( fludrocortisone, transdermal scopolamine, beta-adrenergic blocking agents, disopyramide) were ineffectual, poorly tolerated or contraindicated, were referred for study. Sertraline was administered orally at 50 mg daily for 4 to 6 weeks. A head-upright tilt table test was then reperformed, and the clinical effect was noted. RESULTS: Three patients (18%, 95% confidence interval [CI] 1 to 44) were intolerant of the drug, and it was discontinued. Nine patients became asymptomatic and tilt negative (53%, 95% CI 26 to 76), and five remained tilt positive (36%, 95% CI 15 to 65). Over a mean follow-up period of 12 +/- 5 months, the tilt-negative patients remained symptom free while taking sertraline. CONCLUSIONS:
|
Authors | B P Grubb, D Samoil, D Kosinski, K Kip, P Brewster |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 24
Issue 2
Pg. 490-4
(Aug 1994)
ISSN: 0735-1097 [Print] United States |
PMID | 8034887
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Serotonin Uptake Inhibitors
- 1-Naphthylamine
- Sertraline
|
Topics |
- 1-Naphthylamine
(analogs & derivatives, therapeutic use)
- Adolescent
- Bradycardia
(complications)
- Child
- Female
- Humans
- Hypotension
(complications)
- Male
- Posture
- Recurrence
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Sertraline
- Syncope
(diagnosis, drug therapy, etiology)
|