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Unusual acantholytic bullous dermatosis associated with neoplasia and IgG and IgA antibodies against bovine desmocollins I and II.

Abstract
There are unusual cases of pemphigus that have antibodies nonreactive with either pemphigus vulgaris or pemphigus foliaceus antigens. We describe a patient with an acantholytic bullous dermatosis and lung cancer with intercellular IgG and IgA antibodies that differed in specificity from those of pemphigus vulgaris and pemphigus foliaceus and reacted with bovine desmocollins I and II and recombinant desmocollin protein.
AuthorsT P Chorzelski, T Hashimoto, T Nishikawa, T Ebihara, M Dmochowski, M Ismail, S Jabłońska
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 31 Issue 2 Pt 2 Pg. 351-5 (Aug 1994) ISSN: 0190-9622 [Print] United States
PMID8034804 (Publication Type: Case Reports, Comparative Study, Journal Article, Review)
Chemical References
  • DSC1 protein, human
  • DSC2 protein, human
  • Desmocollins
  • Immunoglobulin A
  • Immunoglobulin G
  • Membrane Glycoproteins
  • Recombinant Proteins
Topics
  • Adult
  • Animals
  • Antibody Specificity
  • Cattle
  • Desmocollins
  • Desmosomes (immunology)
  • Epidermolysis Bullosa (complications, immunology)
  • Humans
  • Immunoglobulin A (analysis)
  • Immunoglobulin G (analysis)
  • Lung Neoplasms (complications, immunology)
  • Male
  • Membrane Glycoproteins (immunology)
  • Pemphigus (immunology)
  • Recombinant Proteins (immunology)

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