Induction of hepatocellular carcinoma in nonhuman primates by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline.

Abstract

The heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was evaluated for carcinogenic effects in macaques, primarily cynomolgus monkeys. IQ was administered by gavage five times a week at doses of 10 or 20 mg/kg. IQ induced hepatocellular carcinoma in 55% of the animals at the low dose and in 95% of the animals at 20 mg/kg. The average latent period at the high dose level was 43 months and that at the low dose was 60 months. Generally, the tumor nodules exhibited a well- to moderately well-differentiated hepatocellular carcinoma, and a trabecular pattern was most frequently seen. Pulmonary metastases were also found in several of the monkeys. Thus, IQ is a potent carcinogen in nonhuman primates and is a potential carcinogen for humans.

• Authors: R H Adamson, S Takayama, T Sugimura, U P Thorgeirsson
• Journal: Environmental health perspectives (Environ Health Perspect) Vol. 102 Issue 2 Pg. 190-3 (Feb 1994) ISSN: 0091-6765 [Print] United States
• PMID: 8033850 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Mutagens
• Quinolines
• 2-amino-3-methylimidazo(4,5-f)quinoline

Topics

• Animals
• Carcinogens
• Carcinoma, Hepatocellular (chemically induced)
• Female
• Food Contamination
• Liver Neoplasms, Experimental (chemically induced)
• Macaca fascicularis
• Macaca mulatta
• Male
• Mutagens (toxicity)
• Quinolines (toxicity)