Abstract |
The heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) was evaluated for carcinogenic effects in macaques, primarily cynomolgus monkeys. IQ was administered by gavage five times a week at doses of 10 or 20 mg/kg. IQ induced hepatocellular carcinoma in 55% of the animals at the low dose and in 95% of the animals at 20 mg/kg. The average latent period at the high dose level was 43 months and that at the low dose was 60 months. Generally, the tumor nodules exhibited a well- to moderately well-differentiated hepatocellular carcinoma, and a trabecular pattern was most frequently seen. Pulmonary metastases were also found in several of the monkeys. Thus, IQ is a potent carcinogen in nonhuman primates and is a potential carcinogen for humans.
|
Authors | R H Adamson, S Takayama, T Sugimura, U P Thorgeirsson |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 102
Issue 2
Pg. 190-3
(Feb 1994)
ISSN: 0091-6765 [Print] United States |
PMID | 8033850
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Carcinogens
- Mutagens
- Quinolines
- 2-amino-3-methylimidazo(4,5-f)quinoline
|
Topics |
- Animals
- Carcinogens
- Carcinoma, Hepatocellular
(chemically induced)
- Female
- Food Contamination
- Liver Neoplasms, Experimental
(chemically induced)
- Macaca fascicularis
- Macaca mulatta
- Male
- Mutagens
(toxicity)
- Quinolines
(toxicity)
|