[Orthoclone OKT3 in the treatment of intractable acute renal allograft rejection].

Abstract

Fifteen patients receiving cadaveric renal allograft had intractable acute rejection during the application cyclosporin-A (Cs-A), from 1991 to 1992. After treating with orthoclone (OKT3, switzerland), 13 patients recovered and 2 died of cerebro-vascular diseases. The main side-effects of OKT3 were sensitization, over-immunosuppression and cytokine release syndrome. The symptoms included chills, fever, dyspnea, diarrhea, pulmonary edema, etc. We consider that when the acute rejection of renal allograft is resistant to Cs-A or steroids, OKT3 is a good therapy with high reverse rate.

• Authors: L X Yu
• Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] (Zhonghua Wai Ke Za Zhi) Vol. 31 Issue 12 Pg. 754-5 (Dec 1993) ISSN: 0529-5815 [Print] China
• PMID: 8033708 (Publication Type: English Abstract, Journal Article)

Chemical References

• Muromonab-CD3
• Cyclosporine

Topics

• Adolescent
• Adult
• Cyclosporine (therapeutic use)
• Female
• Graft Rejection (therapy)
• Humans
• Kidney Transplantation
• Male
• Middle Aged
• Muromonab-CD3 (therapeutic use)