HLA antigens in Arabs with lichen planus.

Abstract

We have HLA typed 50 Arab patients with cutaneous lichen planus who were resident in Kuwait and then compared the antigen incidence with 100 normal controls. There were no significant differences in the antigens of the HLA-ABC loci but there was a significant increase in HLA-DR1 (P = 0.0018, RR = 3.68) and HLA-DR10 (P. corr. = 0.00096, RR = 8.27) and a significant decrease in HLA DR5 (P. corr. = 0.0396, RR = 0.18). The relevance of these findings to earlier reports on lichen planus in which HLA-DR1 (but not DR10) is increased is discussed. This is the first report of HLA antigen frequency in Arab patients with lichen planus, and would support the fact that HLA DR1 is universally associated with the disease, although the more significant association appears to be with HLA-DR10.

• Authors: A G White, A I Rostom
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 19 Issue 3 Pg. 236-7 (May 1994) ISSN: 0307-6938 [Print] England
• PMID: 8033385 (Publication Type: Comparative Study, Journal Article)

Chemical References

• HLA-DR Antigens
• HLA-DR1 Antigen
• HLA-DR5 Antigen
• HLA-DRw10

Topics

• Adolescent
• Adult
• Aged
• Child
• Female
• HLA-DR Antigens (blood)
• HLA-DR1 Antigen (blood)
• HLA-DR5 Antigen (blood)
• Humans
• Incidence
• Kuwait
• Lichen Planus (immunology)
• Male
• Middle Aged