Abstract |
Fourteen hypertensives aged > 66-77 years, whose diastolic blood pressure (DBP) was > or = 95 mmHg at the end of 1-month treatment with verapamil 240 mg SR, took part in this clinical-hemodynamic study. Patients were randomized to add the long-acting hydralazine derivative, cadralazine, 10 mg once daily, or chlorthalidone 25 mg once daily for 1 month each, to their previous verapamil regimen, according to a double-blind crossover design. Echo-Doppler hemodynamics were performed before starting verapamil, 1 month after verapamil and then after each phase of the crossover study. A significant reduction in DBP both in supine and upright position was observed with both drugs, while the reduction in systolic blood pressure was not significant. Criteria for a satisfactory response were DBP < or = 90 mmHg or a DBP reduction > or = 10 mmHg; this goal was achieved in 9 patients with cadralazine, 9 patients with chlorthalidone, 5 patients with both. The hemodynamic study in responders showed that both cadralazine and chlorthalidone acted through a reduction of peripheral resistances without inducing reflex tachycardia. Thus, cadralazine and chlorthalidone represent a suitable second-step treatment in elderly hypertensives insufficiently controlled by verapamil monotherapy: both drugs act through a reduction in total peripheral resistance (TPR).
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Authors | R Antonicelli, S Savonitto, P F Tomassini, C Gambini, M Sardina, E Paciaroni |
Journal | International journal of clinical pharmacology and therapeutics
(Int J Clin Pharmacol Ther)
Vol. 32
Issue 4
Pg. 198-203
(Apr 1994)
ISSN: 0946-1965 [Print] Germany |
PMID | 8032580
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Pyridazines
- cadralazine
- Verapamil
- Chlorthalidone
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Topics |
- Aged
- Antihypertensive Agents
(pharmacology, therapeutic use)
- Blood Pressure
(drug effects)
- Chlorthalidone
(pharmacology, therapeutic use)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Hemodynamics
(drug effects)
- Humans
- Hypertension
(drug therapy)
- Male
- Pyridazines
(pharmacology, therapeutic use)
- Verapamil
(pharmacology, therapeutic use)
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