Antihypertensive property and renal protection by shichimotsu-koka-to extract in salt-induced hypertension in Dahl strain rats.

Abstract

We determined whether or not the kampo formula, Shichimotsu-koka-to extract, attenuates the development of salt-induced hypertension and provides renal protection against hypertensive injury in Dahl salt-sensitive (Dahl S) rats. A six-week treatment using this formula dose-dependently decreased the systolic blood pressure in Dahl S rats fed a high-salt (2% NaCl) diet. This blood pressure reduction was associated with a decrease in the thickness of the aortic wall. Renal function was not altered with this treatment; however, glomerular sclerotic lesions in the kidney were significantly attenuated. Neither arterial nor tubular lesions were affected. These data suggest that Shichimotsukoka-to extract exhibits an antihypertensive effect which is associated with partial resolution of glomerular sclerosis in the kidney.

• Authors: N Hiwara, Y Uehara, S Takada, Y Kawabata, N Ohshima, T Nagata, T Ishimitsu, T Gomi, A Goto, T Ikeda
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 22 Issue 1 Pg. 51-62 ( 1994) ISSN: 0192-415X [Print] Singapore
• PMID: 8030619 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Drugs, Chinese Herbal
• Plant Extracts
• Sodium, Dietary
• Sodium

Topics

• Animals
• Antihypertensive Agents (therapeutic use)
• Blood Pressure (drug effects)
• Cardiovascular System (pathology)
• Drugs, Chinese Herbal (therapeutic use)
• Hypertension (chemically induced, drug therapy, pathology)
• Kidney (pathology)
• Kidney Function Tests
• Organ Size (drug effects)
• Plant Extracts (therapeutic use)
• Rats
• Rats, Inbred Strains
• Sodium (urine)
• Sodium, Dietary
• Urodynamics (drug effects)