Deep vein thrombosis treated with streptokinase or heparin. Follow-up of a randomized study.

Abstract

Twenty-seven patients with deep vein thrombosis whose primary therapy was randomized between streptokinase and heparin were reevaluated clinically and by ascending venography after a mean period of 7 months. Normal venograms were found in 6 (40%) of the streptokinase-treated patients and in 1 patient (8%) who had heparin therapy. Segmental valve preservation was found in 1 patient from each group. All patients with complete or partial valve preservation became asymptomatic. Vein recanalization without preservation of valves occurred in 18 patients: 8 (54%) of those on streptokinase, and 10 (83%) of those on heparin. At the time of follow-up, 11 of these 18 patients, including 8 who had had prior thrombosis, reported peripheral edema; the postphlebitic syndrome developed in 1. Factors favoring a good outcome of acute venous thrombosis were (1) no prior thrombotic disease, (2) localized thrombosis, and (3) prompt streptokinase therapy.

• Authors: H H Common, A J Seaman, J Rösch, J M Porter, C T Dotter
• Journal: Angiology (Angiology) Vol. 27 Issue 11 Pg. 645-54 (Nov 1976) ISSN: 0003-3197 [Print] United States
• PMID: 802925 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Heparin
• Streptokinase

Topics

• Adult
• Clinical Trials as Topic
• Female
• Follow-Up Studies
• Heparin (therapeutic use)
• Humans
• Male
• Middle Aged
• Phlebography
• Random Allocation
• Streptokinase (therapeutic use)
• Thrombophlebitis (diagnostic imaging, drug therapy)
• Time Factors