Abstract | OBJECTIVE: METHODS: A randomized, unblinded, parallel group comparison was performed during the 6 weeks of the ragweed pollen season. Sixty-two adults with ragweed pollen-induced conjunctivitis were recruited for the study from previous ragweed studies and notices in the local media. Two drops of sodium cromoglycate were placed in each eye either four times daily (regular treatment group) or when needed, up to four times daily (prn group), from 1 week before and throughout the ragweed pollen season. Uncontrolled eye symptoms were treated with terfenadine 60 mg as needed, up to 120 mg daily. Subjects kept daily diaries for symptoms and medication requirements throughout the 6 weeks of treatment. The Rhinoconjunctivitis Quality of Life Questionnaire was administered and adverse experiences were reported after 1, 3, and 6 weeks of treatment. RESULTS: Diary eye symptoms were similar in the two treatment groups, but quality of life was better in the regular treatment group. There was a trend for the prn group to require more terfenadine for uncontrolled eye symptoms. CONCLUSIONS:
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Authors | E F Juniper, G H Guyatt, P J Ferrie, D R King |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 94
Issue 1
Pg. 36-43
(Jul 1994)
ISSN: 0091-6749 [Print] United States |
PMID | 8027497
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ophthalmic Solutions
- Beclomethasone
- Cromolyn Sodium
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Topics |
- Adolescent
- Adult
- Aged
- Beclomethasone
(administration & dosage)
- Conjunctivitis, Allergic
(diagnosis, drug therapy)
- Cromolyn Sodium
(administration & dosage)
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Nebulizers and Vaporizers
- Ophthalmic Solutions
- Quality of Life
- Seasons
- Skin Tests
- Time Factors
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