Association of HLA-DPB1*0501 with early-onset Graves' disease in Japanese.

Abstract

To investigate the association between HLA antigens and Graves' disease among Japanese, serologic typing and DPB1 genotyping using the PCR-RFLP method have been performed. HLA alleles of 106 patients with Graves' disease were determined, and the frequency of HLA-B46 was found to be significantly increased. Furthermore, the frequencies of HLA antigens were compared between two age groups: early-onset and late-onset patients (under and over 20 years, respectively). It was found that the frequency of DPB1*0501 (88.9%) was significantly increased (pc < 0.004) in the early-onset group as compared with the healthy controls (55.0%) but not in the late-onset group (60.7%). On the other hand, a significant increase of HLA-B46 was observed in the late-onset patients (pc < 0.0004). These results suggest that the genetic background of Japanese patients with early-onset Graves' disease is different from late-onset patients. Namely, the HLA-DP allele (DPB1*0501) and the HLA-B allele (B46) are primarily involved in the pathogenesis of early-onset and late-onset Graves' disease in Japanese, respectively.

• Authors: H Onuma, M Ota, A Sugenoya, H Inoko
• Journal: Human immunology (Hum Immunol) Vol. 39 Issue 3 Pg. 195-201 (Mar 1994) ISSN: 0198-8859 [Print] United States
• PMID: 8026987 (Publication Type: Journal Article)

Chemical References

• HLA Antigens
• HLA-DP Antigens
• HLA-DP beta-Chains
• HLA-DPB1 antigen
• Triiodothyronine
• Thyroxine

Topics

• Adolescent
• Adult
• Disease Susceptibility (immunology)
• Female
• Genetic Predisposition to Disease
• Graves Disease (genetics, immunology)
• HLA Antigens (genetics)
• HLA-DP Antigens (genetics)
• HLA-DP beta-Chains
• Humans
• Japan
• Male
• Middle Aged
• Polymerase Chain Reaction
• Thyroxine (blood)
• Triiodothyronine (blood)