Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines.

Abstract

1. alpha-Momorcharin, a glycoprotein isolated from seeds of the bitter gourd, Momordica charantia inhibited incorporation of [3H]thymidine, [3H]leucine and [3H]uridine into P388 (mouse monocyte-macrophage), J774 (Balb/c macrophage), JAR (human placental choriocarcinoma) and sarcoma S180 cell lines. 2. The most potent inhibitory effect was exerted on P388 cells and the smallest effect on sarcoma cells. 3. alpha-Momorcharin also enhanced the tumoricidal effect of mouse macrophages on mouse mastocytomal (P815) cells.

• Authors: T B Ng, W K Liu, S F Sze, H W Yeung
• Journal: General pharmacology (Gen Pharmacol) Vol. 25 Issue 1 Pg. 75-7 (Jan 1994) ISSN: 0306-3623 [Print] England
• PMID: 8026716 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Plant Extracts
• Plant Proteins
• Ribosomal Proteins
• Tritium
• MMC protein, Momordica charantia
• Ribosome Inactivating Proteins
• Leucine
• Thymidine
• Uridine

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology)
• Drug Screening Assays, Antitumor
• Humans
• Leucine (metabolism)
• Leukemia P388 (drug therapy, metabolism)
• Macrophages (drug effects, metabolism)
• Mast-Cell Sarcoma (drug therapy, metabolism)
• Mice
• Mice, Inbred BALB C
• Monocytes (drug effects, metabolism)
• Plant Extracts (pharmacology)
• Plant Proteins (pharmacology)
• Ribosomal Proteins
• Ribosome Inactivating Proteins
• Sarcoma 180 (drug therapy, metabolism)
• Thymidine (metabolism)
• Tritium
• Tumor Cells, Cultured (drug effects)
• Uridine (metabolism)