Abstract |
This review examines the animal, human, and mechanistic studies that precede the new studies reported in this volume. Wholly vaporized unleaded gasoline was found to produce a dose-dependent increase in renal carcinoma in male rats and an excess above background incidence of hepatocellular tumors in female mice in the high-dose group. Mechanistic studies suggest that gasoline is not mutagenic and that the probable mechanism for the male rat renal tumors involves a rat-specific protein, alpha 2u-globulin, whose binding with highly branched aliphatic compounds results in renal tubule cell death and, in turn, a proliferative sequence that increases renal tubule tumors. Human evidence generated predominantly from studies of refinery workers does not support a kidney or liver cancer risk in humans. The current epidemiologic database is inadequate to access leukemia risk from low-level benzene exposure from gasoline. Studies of gasoline-exposed workers that incorporate quantitative exposure information are needed.
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Authors | G K Raabe |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 101 Suppl 6
Pg. 35-8
(Dec 1993)
ISSN: 0091-6765 [Print] United States |
PMID | 8020448
(Publication Type: Journal Article)
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Chemical References |
- Carcinogens
- Carcinogens, Environmental
- Gasoline
|
Topics |
- Animals
- Carcinogens
(toxicity)
- Carcinogens, Environmental
(adverse effects)
- Female
- Gasoline
(adverse effects, analysis, toxicity)
- Humans
- Male
- Mutagenicity Tests
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