Abstract |
The effects of 3,9-bis(N,N-dimethylcarbamoyloxy)-5H-benzofuro[3,2-c]quinoli ne-6-one (KCA-098), a derivative of coumestrol, on bone resorption was studied in organ cultures of 20-day fetal rat femora. KCA-098 increased the length, dry weight, and calcium and phosphorus contents of parathyroid hormone (PTH)-treated fetal rat femur. As PTH significantly reduced the calcium and phosphorus contents of the femora, probably by stimulating bone resorption, KCA-098 seems to inhibit bone resorption. In fact, KCA-098 inhibited the PTH-induced release of 45Ca from pre-labeled fetal rat femora into the medium in organ culture. Coumestrol also inhibited the release of 45Ca from bone into the medium. However, KCA-098 did not increase the uterine weight of ovariectomized rats, whereas coumestrol did so. Thus KCA-098 is a unique, new inhibitor of bone resorption that has no estrogenic activity.
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Authors | N Tsutsumi, K Kawashima, N Arai, H Nagata, M Kojima, A Ujiie, H Endo |
Journal | Bone and mineral
(Bone Miner)
Vol. 24
Issue 3
Pg. 201-9
(Mar 1994)
ISSN: 0169-6009 [Print] Ireland |
PMID | 8019207
(Publication Type: Journal Article)
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Chemical References |
- Parathyroid Hormone
- KCA 098
- Phosphorus
- Estradiol
- Calcium
- Coumestrol
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Topics |
- Animals
- Bone Resorption
(embryology)
- Calcification, Physiologic
- Calcium
(metabolism)
- Coumestrol
(analogs & derivatives, pharmacology)
- Estradiol
(pharmacology)
- Female
- Femur
(embryology, physiology)
- Organ Culture Techniques
- Organ Size
(drug effects)
- Ovariectomy
- Parathyroid Hormone
(pharmacology)
- Phosphorus
(metabolism)
- Pregnancy
- Rats
- Rats, Wistar
- Uterus
(anatomy & histology)
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