Abstract |
Multiple sclerosis (MS) has been associated with HLA-DR2 for more than 20 years, and a large number of studies have addressed the relation between MS and the HLA class II genes, which are our major immune-response genes. This has produced a complex and confusing picture that is difficult to interpret. With the advent of reliable and comprehensive DNA-based typing techniques, it is now possible to extract a coherent pattern from this mass of data. The associated haplotype has been specified to HLA-Dw2 in cellular typing nomenclature, which equals DR15,DQ6 by serology, and DRB1*1501,DQA1*0102,DQB1*0602 in sequence-based terminology. This haplotype is increased among groups of MS patients worldwide, although most strongly in North and West Europeans, and it is the only haplotype with a clear importance in MS. Attempts to map this association within the haplotype have not been successful.
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Authors | J Hillert |
Journal | Annals of neurology
(Ann Neurol)
Vol. 36 Suppl
Pg. S15-7
( 1994)
ISSN: 0364-5134 [Print] United States |
PMID | 8017880
(Publication Type: Journal Article, Review)
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Chemical References |
- HLA Antigens
- HLA-D Antigens
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Topics |
- Alleles
- Europe
- HLA Antigens
(genetics, immunology)
- HLA-D Antigens
(genetics, immunology)
- Haplotypes
- Humans
- Multiple Sclerosis
(genetics, immunology)
- Racial Groups
(genetics)
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