Response to suxamethonium during propofol-fentanyl-N2O/O2 anaesthesia in a patient with active myasthenia gravis receiving long-term anticholinesterase therapy.

Abstract	We describe the effect of repeated suxamethonium doses during propofol-fentanyl-N2O/O2 anaesthesia in a 29-year-old woman with active myasthenia gravis receiving chronic pyridostigmine therapy. Despite adequate pre-operative pseudocholinesterase activity, suxamethonium resistance occurred. Neither bradycardia nor residual neuromuscular block were seen after repeated doses of suxamethonium.
Authors	L E Vanlinthout, E N Robertson, L H Booij
Journal	Anaesthesia (Anaesthesia) Vol. 49 Issue 6 Pg. 509-11 (Jun 1994) ISSN: 0003-2409 [Print] England
PMID	8017595 (Publication Type: Case Reports, Journal Article)
Chemical References	Succinylcholine Nitrous Oxide Pyridostigmine Bromide Oxygen Propofol
Topics	Adult Anesthesia, Inhalation Anesthesia, Intravenous Dose-Response Relationship, Drug Drug Resistance Female Humans Muscle Contraction (drug effects) Myasthenia Gravis (drug therapy, enzymology, physiopathology, surgery) Nitrous Oxide Oxygen Propofol Pyridostigmine Bromide (therapeutic use) Succinylcholine (pharmacology)

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