Treatment of interstitial cystitis with intravesical heparin.

Abstract

OBJECTIVE:

To control the symptoms of interstitial cystitis with chronic self-administered intravesical heparin and determine whether the drug's continued use can sustain remission.

PATIENTS AND METHODS:

A total of 48 patients were selected to undergo intravesical heparin therapy, 10,000 units in 10 ml sterile water, three times per week for 3 months. For patients who attained a good clinical remission, therapy was available for up to a further 9 months.

RESULTS:

At 3 months 27 of 48 patients (56%) attained good clinical remissions. All were offered continuous therapy and 23 elected for an additional 3 months. Twenty of the 23 continued in remission. Sixteen of these patients elected to have a further 6 months of therapy (12 months total) and 15 of 16 remained in remission.

CONCLUSION:

In over half of the patients studied, intravesical heparin controls the symptoms of interstitial cystitis with continued improvement even after one year of therapy.

• Authors: C L Parsons, T Housley, J D Schmidt, D Lebow
• Journal: British journal of urology (Br J Urol) Vol. 73 Issue 5 Pg. 504-7 (May 1994) ISSN: 0007-1331 [Print] England
• PMID: 8012771 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Heparin

Topics

• Administration, Intravesical
• Adult
• Aged
• Cystitis (drug therapy, physiopathology)
• Drug Administration Schedule
• Female
• Follow-Up Studies
• Heparin (administration & dosage)
• Humans
• Male
• Middle Aged
• Self Administration
• Urination (drug effects)