Anipamil prevents ST depression in patients with stable angina pectoris.

Abstract

The purpose of this study was to examine the 24-hour antiischemic efficacy of once-a-day anipamil compared to placebo in the treatment of patients with stable angina. The study was designed as a double-blind, placebo-controlled crossover study with an initial 3 week single-blind placebo period. The patients received anipamil 80 mg once daily, anipamil 160 mg once daily, and placebo in a randomized order. At the end of each treatment period the patients underwent 24-hour ambulatory ECG recording. Nineteen patients were included, all with typical stable angina pectoris for at least 2 months, exercise test with > or = 0.10 mV horizontal or down-sloping ST-segment depression and limited by angina pectoris, and at least 10 attacks of angina pectoris in the initial single-blind placebo period. During the placebo period, a total duration of transient myocardial ischemia > or = 0.10 mV during the 24-hour ambulatory ECG monitoring period was 2263 minutes, 75% of which were asymptomatic. Anipamil 80 mg and 160 mg significantly reduced the duration of episodes to 712 minutes (p < 0.001), with 87% asymptomatic, and to 913 minutes (p > 0.001), with 92% asymptomatic, respectively. In conclusion, anipamil given once a day is an effective 24-hour antiischemic drug in the treatment of transient myocardial ischemia.

• Authors: C T Larsen, C Sørum, V Rasmussen, J Fischer Hansen
• Journal: Cardiovascular drugs and therapy (Cardiovasc Drugs Ther) Vol. 7 Issue 6 Pg. 915-21 (Dec 1993) ISSN: 0920-3206 [Print] United States
• PMID: 8011571 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Channel Blockers
• Placebos
• Propylamines
• anipamil

Topics

• Aged
• Angina Pectoris (blood, drug therapy)
• Calcium Channel Blockers (adverse effects, blood, therapeutic use)
• Double-Blind Method
• Drug Administration Schedule
• Electrocardiography, Ambulatory (drug effects)
• Female
• Humans
• Male
• Middle Aged
• Myocardial Ischemia (prevention & control)
• Placebos
• Propylamines (adverse effects, blood, therapeutic use)
• Single-Blind Method