Abstract |
The effects of 1,6-dihydro-2-[2-(2-methylpropoxy) anilino]-6-oxo-5-pyrimidinecarboxylic acid (MAR-99, CAS 98772-05-5) on various experimental gastric ulcers were studied in rats. MAR-99 (3-100 mg/kg, p.o. or i.d.) showed the anti- ulcer effect in Shay-, stress, acetylsalicylic acid (ASA)- and compound 48/80- ulcer models and significantly accelerated healing of acetic acid-induced gastric ulcer in rats. In addition, MAR-99 (1-10 mg/kg p.o.) decreased dose-dependently the gastric mucosal damage induced by necrotizing agents such as 99.5% ethanol, 0.6N HCl and 0.2 N NaOH. These results indicate that MAR-99 may be useful for the treatment of gastric ulcer in human.
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Authors | Y Ishizuka, T Kamisaki, M Matsuda, I Shimazaki, M Kawashima, H Yaginuma, K Terashima, M Sato |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 44
Issue 4
Pg. 509-13
(Apr 1994)
ISSN: 0004-4172 [Print] Germany |
PMID | 8011005
(Publication Type: Journal Article)
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Chemical References |
- Acetates
- Anti-Ulcer Agents
- Pyrimidines
- Ethanol
- p-Methoxy-N-methylphenethylamine
- Sodium Hydroxide
- cetraxate
- Tranexamic Acid
- Cimetidine
- MAR 99
- Hydrochloric Acid
- Aspirin
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Topics |
- Acetates
- Animals
- Anti-Ulcer Agents
(chemical synthesis, pharmacology)
- Aspirin
- Cimetidine
(pharmacology)
- Ethanol
- Hydrochloric Acid
- Male
- Pylorus
(physiology)
- Pyrimidines
(chemical synthesis, pharmacology)
- Rats
- Rats, Sprague-Dawley
- Sodium Hydroxide
- Stomach Ulcer
(chemically induced, etiology, prevention & control)
- Stress, Psychological
(complications)
- Tranexamic Acid
(analogs & derivatives, pharmacology)
- p-Methoxy-N-methylphenethylamine
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