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Anti-ulcer effect of 1,6-dihydro-2-[2-(2-methylpropoxy) anilino]-6-oxo-5-pyrimidinecarboxylic acid on experimental gastric ulcers in rats.

Abstract
The effects of 1,6-dihydro-2-[2-(2-methylpropoxy) anilino]-6-oxo-5-pyrimidinecarboxylic acid (MAR-99, CAS 98772-05-5) on various experimental gastric ulcers were studied in rats. MAR-99 (3-100 mg/kg, p.o. or i.d.) showed the anti-ulcer effect in Shay-, stress, acetylsalicylic acid (ASA)- and compound 48/80-ulcer models and significantly accelerated healing of acetic acid-induced gastric ulcer in rats. In addition, MAR-99 (1-10 mg/kg p.o.) decreased dose-dependently the gastric mucosal damage induced by necrotizing agents such as 99.5% ethanol, 0.6N HCl and 0.2 N NaOH. These results indicate that MAR-99 may be useful for the treatment of gastric ulcer in human.
AuthorsY Ishizuka, T Kamisaki, M Matsuda, I Shimazaki, M Kawashima, H Yaginuma, K Terashima, M Sato
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 44 Issue 4 Pg. 509-13 (Apr 1994) ISSN: 0004-4172 [Print] Germany
PMID8011005 (Publication Type: Journal Article)
Chemical References
  • Acetates
  • Anti-Ulcer Agents
  • Pyrimidines
  • Ethanol
  • p-Methoxy-N-methylphenethylamine
  • Sodium Hydroxide
  • cetraxate
  • Tranexamic Acid
  • Cimetidine
  • MAR 99
  • Hydrochloric Acid
  • Aspirin
Topics
  • Acetates
  • Animals
  • Anti-Ulcer Agents (chemical synthesis, pharmacology)
  • Aspirin
  • Cimetidine (pharmacology)
  • Ethanol
  • Hydrochloric Acid
  • Male
  • Pylorus (physiology)
  • Pyrimidines (chemical synthesis, pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Sodium Hydroxide
  • Stomach Ulcer (chemically induced, etiology, prevention & control)
  • Stress, Psychological (complications)
  • Tranexamic Acid (analogs & derivatives, pharmacology)
  • p-Methoxy-N-methylphenethylamine

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