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[C-fos expression in rat brain during seizure and electroacupuncture].

Abstract
C-fos proteins were visualized immunohistochemically in the brain of rats after seizures induced by injecting penicillin into hippocampus and by penicillin+electroacupuncture treatment. Three hours following seizures there was an evident expression of c-fos proteins in the hippocampus (CA1 area), dentate gyrus, piriform cortex, dorsal part of entorhinal cortex, and amygdaloid nucleus, and there was a dramatic increase of c-fos proteins in CA3 area and the areas mentioned above except the CA1 area where c-fos proteins apparently decreased after electroacupuncture treatment. The results showed that seizures can induce c-fos proteins in some nuclei related with seizure and that electroacupuncture can also regulates the c-fos expression after seizure.
AuthorsB E Wang, J S Cheng
JournalZhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 15 Issue 1 Pg. 73-5 (Jan 1994) ISSN: 0253-9756 [Print] China
PMID8010091 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Penicillins
  • Proto-Oncogene Proteins c-fos
Topics
  • Animals
  • Brain (metabolism)
  • Electroacupuncture
  • Epilepsy (chemically induced, metabolism)
  • Female
  • Gene Expression Regulation
  • Hippocampus (metabolism)
  • Male
  • Penicillins
  • Proto-Oncogene Proteins c-fos (biosynthesis, genetics)
  • Rats
  • Rats, Wistar

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