Management of spasticity in cerebral palsy with botulinum-A toxin: report of a preliminary, randomized, double-blind trial.

Abstract

In order to evaluate further the efficacy of local intramuscular injections of botulinum-A toxin (BAT-A) in the management of dynamic equinus deformity associated with cerebral palsy, a randomized, double-blind, placebo-controlled study was undertaken. When evaluated using our Physician Rating Scale, 83% (five of six) of patients receiving toxin showed improvement, versus 33% (two of six) receiving placebo. There were no major complications. BAT-A injections appear to be safe and effective in children, and merit further prospective study.

• Authors: L A Koman, J F Mooney 3rd, B P Smith, A Goodman, T Mulvaney
• Journal: Journal of pediatric orthopedics (J Pediatr Orthop) 1994 May-Jun Vol. 14 Issue 3 Pg. 299-303 ISSN: 0271-6798 [Print] United States
• PMID: 8006158 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Botulinum Toxins

Topics

• Botulinum Toxins (administration & dosage, therapeutic use)
• Cerebral Palsy (complications, drug therapy)
• Child
• Child, Preschool
• Double-Blind Method
• Foot Deformities, Acquired (drug therapy, etiology)
• Gait
• Humans
• Injections, Intramuscular
• Muscle Spasticity (drug therapy)
• Range of Motion, Articular