Prognosis and management of membraneous nephropathy.

Abstract

Patients of idiopathic membranous nephropathy (MGN) were randomly assigned to received steroid and cyclophosphamide every other month (Gr-I) and steroid alone (Gr-II). Of 36 patients in Gr.I, 33 patients achieved complete remissions, 2 had relapsing course with remission on further courses of therapy and only one has reached end stage renal failure. In contrast, of the 35 patients in Gr. II, 15 (P < 0.001) achieved complete remission, 7 are in partial remission, 5 have no response, another 5 have deterioration of renal function of which two required dialysis, and 3 have relapsing course after the initial remission. Mean follow up period was 46 +/- 10.2 months. We conclude that steroid and cyclophosphamide every other month is highly effective in achieving remission in patients with membranous nephropathy.

• Authors: D K Pahari, S Das, B N Dutta, D Banerjee
• Journal: The Journal of the Association of Physicians of India (J Assoc Physicians India) Vol. 41 Issue 6 Pg. 350-1 (Jun 1993) ISSN: 0004-5772 [Print] India
• PMID: 8005970 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Cyclophosphamide
• Prednisolone

Topics

• Adolescent
• Adult
• Aged
• Cyclophosphamide (administration & dosage, adverse effects)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Glomerulonephritis, Membranous (drug therapy)
• Humans
• Male
• Middle Aged
• Prednisolone (administration & dosage, adverse effects)
• Prognosis