Serum levels of androstanediol glucuronide, total testosterone, and free testosterone in hirsute women.

Abstract

OBJECTIVE:

To determine the serum levels of androstanediol glucuronide (3 alpha-diol G), total T, and free T in hirsute and nonhirsute women.

DESIGN:

Controlled clinical study.

PATIENTS:

Hirsute women with oligomenorrhea, hirsute women with regular ovulatory cycles, and nonhirsute women with regular cycles were selected.

MAIN OUTCOME MEASURE:

Serum levels of 3 alpha-diol G, total T, and free T were measured in 8 hirsute with oligomenorrhea and 11 hirsute women with regular ovulatory cycles and compared with 20 nonhirsute women with regular cycles (control group). Serum 3 alpha-diol G was also measured during the follicular, periovulatory, and luteal phases in hirsute women with regular cycles.

RESULTS:

Serum levels of 3 alpha-diol G did not change during the menstrual cycle, in addition we observed that there was no difference between the levels of 3 alpha-diol G, total T, and free T in hirsute women with regular cycles when compared with normal women. These three serum androgens were elevated only in the hirsute women with oligomenorrhea. Besides, there was better correlation between total T and free T (r = 0.81) than total T and 3 alpha-diol G (r = 0.49) or free T and 3 alpha-diol G (r = 0.66).

CONCLUSION:

The findings suggest that serum 3 alpha-diol G does not provide additional benefit as a marker of hirsutism than serum total or free T.

• Authors: M Y Khoury, E C Baracat, D P Pardini, J G Vieira, G R de Lima
• Journal: Fertility and sterility (Fertil Steril) Vol. 62 Issue 1 Pg. 76-80 (Jul 1994) ISSN: 0015-0282 [Print] United States
• PMID: 8005308 (Publication Type: Journal Article)

Chemical References

• Androstane-3,17-diol
• androstane-3,17-diol glucuronide
• Testosterone
• Dehydroepiandrosterone
• Dehydroepiandrosterone Sulfate
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Adolescent
• Adult
• Androstane-3,17-diol (analogs & derivatives, blood)
• Dehydroepiandrosterone (analogs & derivatives, blood)
• Dehydroepiandrosterone Sulfate
• Female
• Follicle Stimulating Hormone (blood)
• Hirsutism (blood)
• Humans
• Luteinizing Hormone (blood)
• Menstrual Cycle (blood)
• Testosterone (blood)