Complete remission of metastasized adrenocortical carcinoma under o,p'-DDD.

Abstract

The case of a 53 year old female patient with metastasized androgen producing adrenocortical carcinoma is presented. After initial adrenalectomy a local relapse had been treated by surgery and external irradiation. Solitary liver metastases had been resected repeatedly. Subsequently multiple liver metastases required systemic chemotherapy. Treatment with o,p'-DDD (initially 12 g/d, long term treatment 1.5-3 g/d) has resulted in a complete remission for nearly 4 years. Gastrointestinal side effects occurred initially but subsided with dose reduction of o,p'-DDD.

• Authors: E Kornely, R Schlaghecke
• Journal: Experimental and clinical endocrinology (Exp Clin Endocrinol) Vol. 102 Issue 1 Pg. 50-3 ( 1994) ISSN: 0232-7384 [Print] Germany
• PMID: 8005209 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mitotane

Topics

• Adrenal Cortex Neoplasms (drug therapy, radiotherapy, surgery)
• Adrenalectomy
• Female
• Humans
• Liver Neoplasms (drug therapy, secondary)
• Middle Aged
• Mitotane (administration & dosage, adverse effects, therapeutic use)
• Remission Induction