The saluretic effect of the thiazide diuretic bemetizide in relation to the glomerular filtration rate.

Abstract

The effect of the thiazide diuretic, bemetizide, on the excretion of Na+, K+, Cl-, Ca2+, and Mg2+ in relation to the glomerular filtration rate (GFR) was studied in 17 subjects whose creatinine clearances ranged from 133 to 5 ml.min-1. After a 2-day fluid and salt balanced control period, 25 mg bemetizide given orally induced natriuresis and kaliuresis which lasted for 24 h and were proportional to the GFR of the patients. The ratio of bemetizide-induced K+/Na+ excretion was always 0.17 irrespective of individual GFR. In renal failure, bemetizide increased the fractional Na+ excretion from 3% to about 10%. Kaliuresis was associated with magnesiuria, whereas bemetizide-induced calciuresis was insignificant. The thiazide reversibly lowered GFR in all subjects.

• Authors: H Knauf, W Cawello, G Schmidt, E Mutschler
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 46 Issue 1 Pg. 9-13 ( 1994) ISSN: 0031-6970 [Print] Germany
• PMID: 8005195 (Publication Type: Journal Article)

Chemical References

• Benzothiadiazines
• Diuretics
• Electrolytes
• Sodium Chloride Symporter Inhibitors
• dehydrosanol

Topics

• Adult
• Aged
• Benzothiadiazines (pharmacology)
• Diuresis (drug effects)
• Diuretics
• Electrolytes (urine)
• Female
• Glomerular Filtration Rate (drug effects)
• Humans
• Kidney Failure, Chronic (urine)
• Kidney Function Tests
• Male
• Middle Aged
• Natriuresis (drug effects)
• Sodium Chloride Symporter Inhibitors (pharmacology)