Abstract |
The hairy roots of Trichosanthes kirilowii Max, var. japonica Kitam. were induced by Agrobacterium rhizogenes (TCC 15834) on sterile shoots. The axenic culture of hairy roots proliferated 30 to 60-fold based on the initial fresh weight after three weeks of culture in Murashige & Skoog liquid media. Bryonolic acid as the main triterpenoid was isolated in a high yield, together with chondrillasterol from the hairy roots of this plant. Bryonolic acid showed strong inhibition of the growth of B-16 melanoma cells.
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Authors | T Takeda, T Kondo, H Mizukami, Y Ogihara |
Journal | Chemical & pharmaceutical bulletin
(Chem Pharm Bull (Tokyo))
Vol. 42
Issue 3
Pg. 730-2
(Mar 1994)
ISSN: 0009-2363 [Print] Japan |
PMID | 8004724
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Triterpenes
- bryonolic acid
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Topics |
- Antineoplastic Agents, Phytogenic
(biosynthesis, pharmacology)
- Cell Survival
(drug effects)
- Medicine, Chinese Traditional
- Melanoma, Experimental
(drug therapy, physiopathology)
- Plants, Medicinal
(metabolism)
- Rhizobium
(metabolism)
- Triterpenes
(metabolism, pharmacology)
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