Abstract |
Systemic amyloidosis is a rare disorder and usually occurs in aged persons with a poor prognosis. Certain mucocutaneous symptoms and signs may act as important clues for diagnosis. Skin or tongue biopsy may also provide important information to establish a firm diagnosis. During the past 14-year period, we found 19 cases of systemic amyloidoses: 8 (42%) with primary systemic amyloidosis, 8 (42%) associated with multiple myeloma and 3 (16%) were secondary amyloidosis. Ages of the patients ranged from 52 to 71 years with a mean age of 62 years at diagnosis. Median survival was only 8 months. Mucocutaneous manifestations were found in both primary type and myeloma-associated amyloidosis. In addition to the existence of amyloid in tongue and rectum biopsies in 17 cases and abdominal fat aspiration in 1 case, biopsies from clinically normal-looking skin also showed positive results in 18 out of 19 cases.
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Authors | C K Wong, W J Wang |
Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 189
Issue 1
Pg. 47-51
( 1994)
ISSN: 1018-8665 [Print] Switzerland |
PMID | 8003785
(Publication Type: Journal Article)
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Topics |
- Aged
- Amyloidosis
(complications, mortality, pathology)
- Female
- Humans
- Male
- Middle Aged
- Multiple Myeloma
(complications)
- Survival Rate
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