[Effectiveness of thrice-weekly injection of romurutide for prophylaxis of leukocytopenia during radiation therapy].

Abstract

The effectiveness of thrice-weekly injection of Romurutide for leukocytopenia due to radiation therapy was analyzed. Twenty-two patients were randomly divided into two groups. Ten of group A cases were injected 3 times per week 10 times (3 weeks) and 12 of group B cases were injected 5 times per week 10 times (2 weeks). White blood cell counts and neutrophil numbers in group A were almost the same as in group B at day-3 and day-8, and those in group A were more than in group B at day-15 and day-22, although there were no statistical significances. Lymphocyte percentages, monocyte percentages and platelet cell counts between groups showed no differences. Injections were stopped in 3 cases due to fever (2 in group A, 1 in group B). The effects were recognized in nineteen cases (excluding above 3 cases). The effect of this thrice-weekly injection method during the injection period was the same or more than with 5 injections/week, and the period of the former was 50% longer. The 3 weekly injection method is more effective for prophylaxis of leukocytopenia.

• Authors: J Kawamori, T Saito, T Maeno, H Muto
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 21 Issue 7 Pg. 1057-62 (Jun 1994) ISSN: 0385-0684 [Print] Japan
• PMID: 8002621 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Acetylmuramyl-Alanyl-Isoglutamine
• romurtide

Topics

• Acetylmuramyl-Alanyl-Isoglutamine (administration & dosage, analogs & derivatives)
• Breast Neoplasms (radiotherapy)
• Drug Administration Schedule
• Female
• Humans
• Injections, Subcutaneous
• Leukopenia (prevention & control)
• Lung Neoplasms (radiotherapy)
• Male
• Middle Aged
• Neoplasms (radiotherapy)
• Uterine Cervical Neoplasms (radiotherapy)