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Acute stroke intervention with intraarterial urokinase infusion.

AbstractPURPOSE:
A preliminary evaluation of the efficacy and safety of treating patients with acute stroke with intraarterial urokinase infusions was performed.
PATIENTS AND METHODS:
Twelve patients with acute stroke were treated within 8 hours of symptom onset (average, 5 hours). Thrombolysis was performed within the middle cerebral (n = 10), internal carotid (n = 1), and basilar (n = 1) arteries. Urokinase (160,000-500,000 IU) was infused through microcatheters placed into or adjacent to the thrombi.
RESULTS:
Thrombolysis was angiographically successful in nine patients (75%), all of whom had long-term neurologic improvement. No or minimal neurologic deficits were present in six patients (50%). Thrombolysis failed in three patients (25%); one patient died and two developed severe permanent neurologic deficits. No hemorrhagic complications occurred.
CONCLUSION:
Preliminary results suggest that intraarterial urokinase infusion may be effective and safe for treating patients with acute stroke. Potentially devastating neurologic damage was averted or lessened in nine patients (75%). No additional neurologic damage was caused by intervention in the remaining three patients (25%).
AuthorsJ D Barr, J M Mathis, S L Wildenhain, L Wechsler, C A Jungreis, J A Horton
JournalJournal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) 1994 Sep-Oct Vol. 5 Issue 5 Pg. 705-13 ISSN: 1051-0443 [Print] UNITED STATES
PMID8000119 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Urokinase-Type Plasminogen Activator
Topics
  • Cerebral Angiography
  • Cerebral Arteries
  • Cerebrovascular Disorders (complications, drug therapy, radiography)
  • Female
  • Humans
  • Infusions, Intra-Arterial
  • Male
  • Middle Aged
  • Nervous System Diseases (prevention & control)
  • Thrombolytic Therapy (methods)
  • Time Factors
  • Treatment Outcome
  • Urokinase-Type Plasminogen Activator (administration & dosage, therapeutic use)

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