Development of Graves' ophthalmopathy and uveitis after radioiodine therapy for Graves' disease in a patient with HTLV-I associated myelopathy (HAM).

Abstract

HTLV-I carriers or patients with HTLV-I associated myelopathy (HAM) are prone to immune-mediated inflammatory disorders. We present a 44-year-old female with HAM who developed Graves' disease. She developed severe Graves' ophthalmopathy shortly after 131I therapy, concurrently with a remarkable increase in TSH-receptor antibody titer. Ophthalmopathy was aggravated in spite of prednisolone therapy and euthyroidism being maintained by thyroxine replacement. Uveitis also developed after 131I therapy and iridocyclitis finally required trabeculotomy. This case suggests that HAM patients may have a higher risk of immune-mediated Graves' ophthalmopathy after 131I therapy.

• Authors: Y Ozawa, M Migita, T Watanabe, I Okuda, A Takeshita, A Takagi, Y Shishiba
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 33 Issue 9 Pg. 564-8 (Sep 1994) ISSN: 0918-2918 [Print] Japan
• PMID: 8000111 (Publication Type: Case Reports, Journal Article)

Chemical References

• Iodine Radioisotopes
• Prednisolone

Topics

• Adult
• Exophthalmos (drug therapy, etiology)
• Eye Diseases (etiology, therapy)
• Female
• Glaucoma (chemically induced, surgery)
• Graves Disease (complications, drug therapy, radiotherapy)
• Humans
• Iodine Radioisotopes (adverse effects, therapeutic use)
• Paraparesis, Tropical Spastic (complications)
• Prednisolone (adverse effects, therapeutic use)
• Trabeculectomy
• Uveitis (drug therapy, etiology)